Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts

Recruiting now · Not applicable

Conditions studied: Periodontitis, Intrabony Periodontal Defect, Periodontal Diseases, Periodontal Defect, Periodontal Bone Loss

In brief

The use of injectable platelet-rich fibrin (i-PRF) in both surgical and non-surgical dental treatments has become increasingly widespread. Hard tissue grafts can produce "sticky bone," and bone gain can have a positive effect on intrabony defects frequently seen in periodontal disease, compared to grafts alone. This study aims to clinically and radiographically evaluate the effectiveness of using bovine-derived xenogenic bone grafts in combination with i-PRF and bovine-derived xenogeneic bone grafts alone in patients with intrabony defects and stage III periodontitis.

Key facts

Study ID

NCT07146776

Run by

Saglik Bilimleri Universitesi

People needed

16

Starts

2025-07-12

Expected to finish

2026-07-01

Last updated by the study team

2025-09-08

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male and female patients aged 18-65 years
• Patients with Stage III Periodontitis according to the AAP-EFP 2017 Periodontal Disease Classification
• PPD≥5 mm (if persistent 6 weeks after initial periodontal treatment)
• Intrabony defects in the interproximal region with 2 or 3 walls and a depth of at least ≥3 mm
• Non-smokers (those who smoke up to 10 per day may be included)

You may not qualify if…

• Patients under 18 years of age or older than 65 years of age
• Patients unable to consent
• Systemic diseases that could affect the success of surgery, such as uncontrolled diabetes
• Single-walled intrabony defects
• Those who have taken antibiotics, anti-inflammatory or immunosuppressive drugs, or birth control pills within the three months prior to the study
• Those who have received active periodontal treatment within the last six months and periodontal surgery within the last year
• Smoking more than 10 cigarettes per day
• Pregnancy or breastfeeding
• Those taking medications that affect the gums (e.g., calcium channel blockers, phenytoin or cyclosporine)
• Teeth with furcation defects
• Those undergoing active orthodontic treatment
• Those who are allergic to the biomaterials used in the study or prescribed medications

Where it is running

• Sağlık Bilimleri Üniversitesi — Istanbul, Üsküdar, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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