Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study

Starting soon · Phase 4

Conditions studied: Rebound Pain, Shoulder Arthroplasty, Interscalene Block

In brief

Randomized control study that compares different concentrations of local anesthetic to investigate whether a lower concentration of local anesthetic would contribute to lower rebound pain scores at 24 hours post op in patients undergoing anatomic or reverse total shoulder arthroplasty.

Key facts

Study ID

NCT07146685

Run by

University of Virginia

People needed

168

Starts

2026-01-01

Expected to finish

2029-01-01

Last updated by the study team

2025-08-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Total shoulder replacement patients (anatomic and reverse)
• Adult patients (greater than or equal to 18 years)
• Any gender
• Any race

You may not qualify if…

• - Chronic Pain diagnoses including:
• substance/opioid use disorder
• complex regional pain syndromes
• fibromyalgia
• Daily persistent opioid use spanning 3 months prior to surgery date
• Allergy to local anesthetics or NSAIDS
• Respiratory pathologies including:
• CPAP- non-compliant / untreated obstructive sleep apnea
• COPD
• Restrictive lung disease (pulmonary fibrosis, interstitial pneumonia, etc)
• Contralateral diaphragm dysfunction
• BMI > 40
• Ipsilateral extremity pre-existing nerve injury
• GFR < 60
• NSAID contraindications
• Inability to follow up
• Revision surgery
• Patients requesting block as primary (avoidance of general anesthesia)
• Need or request for brachial plexus catheter or liposomal bupivacaine
• Vulnerable populations (pregnancy, incarceration, etc)
• non-English speaking

Where it is running

• UVA Health — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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