Transcranial Magnetic Stimulation and Psychotherapy for Treating Obsessive-Compulsive Disorder
Recruiting now · Not applicable
Conditions studied: Obsessive - Compulsive Disorder
In brief
This study will test how people with OCD respond to a type of noninvasive brain stimulation, repetitive Transcranial Magnetic Stimulation (rTMS), when it is combined with psychotherapy. Participants will either engage in Exposure and Response Prevention (ERP) Therapy or supportive therapy (ST) while receiving rTMS. Biobehavioral data from wearable devices and smartphones will be collected to better predict treatment responses. Participants will also undergo repeat resting state functional Magnetic Resonance Imaging (rsfMRI) in order to assess neural predictors and mechanisms of treatment response.
Key facts
- Study ID
- NCT07146438
- Run by
- Adam Frank
- People needed
- 48
- Starts
- 2025-11-10
- Expected to finish
- 2028-08-01
- Last updated by the study team
- 2025-10-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of Obsessive-Compulsive Disorder (OCD) as determined by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria.
- Live in Southern California and be willing to attend in-person to receive repetitive Transcranial Magnetic Stimulation (rTMS) 5 times per week for 6 weeks.
- Have completed a prior course of Exposure and Response Prevention (ERP) therapy (at least ten sessions)
- Currently take or have previously tried Serotonin Reuptake Inhibitor (SRI) medication for OCD
- Willing to maintain psychotropic medication levels throughout the 16 weeks of the study
You may not qualify if…
- Primary psychiatric diagnosis other than OCD
- Active substance use disorder
- Active suicidality
- Active psychosis
- History of seizures
- Severe neurological impairment
- Pregnant or planning to become pregnant
- Received a prior rTMS course
Where it is running
- University of Southern California Health Sciences Campus — Los Angeles, California, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.