Induced Pluripotent Stem Cells-derived Small Extracellular Vesicles May Promote Neurological Function and Improve Cognitive Impairment in Acute Ischemic Stroke Patients
Recruiting now · Phase 1/Phase 2
Conditions studied: Cognitive Impairment
In brief
This study primarily evaluates whether iEV nasal administration can improve neurological impairment and cognitive dysfunction in patients with acute cerebral infarction and cognitive impairment, and preliminarily explores its clinical efficacy.
Key facts
- Study ID
- NCT07145294
- Run by
- Hongmei Wang
- People needed
- 40
- Starts
- 2025-03-07
- Expected to finish
- 2026-01-01
- Last updated by the study team
- 2025-08-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years old.
- Diagnosed with acute ischemic stroke (AIS) according to WHO criteria.
- Time from onset to enrollment ≤ 2 weeks (stable condition after admission and able to cooperate with cognitive assessment), accompanied by manifestations of cognitive impairment, with a score of < 26 on the Montreal Cognitive Assessment (MoCA) scale.
- Cerebral MRI or CT scan shows stroke lesions related to the condition.
- Subjects or their family members voluntarily participate and sign the informed consent form.
You may not qualify if…
- A diagnosis of cognitive impairment prior to the onset of AIS;
- Presence of aphasia, hearing impairment, visual impairment, dysarthria, or other conditions that prevent completion of neuropsychological assessments;
- Patients with mental illnesses such as depression, anxiety disorder, or schizophrenia;
- Patients with severe diseases of the heart, liver, lungs, kidneys, or other vital organs;
- Patients with disturbed consciousness, a history of long-term alcohol consumption, a history of severe head trauma, or those who cannot cooperate with cognitive function tests for various reasons;
- illiterate patients.
Where it is running
- Shanghai Sixth People's Hospital — Shanghai, China (enrolling)
Full record on ClinicalTrials.gov
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