Anastomotic Leakage After Colorectal Surgery.

Recruiting now

Conditions studied: Anastomotic Leak, Colorectal Cancer, Diverticulitis

In brief

Anastomotic leakage (AL) is a severe complication after colorectal surgery, with incidence rates of 2-30%. This prospective, single-center observational cohort study aims to identify and quantify independent risk factors for AL, determine its incidence and impact on outcomes, and develop a predictive model. Approximately 430 patients undergoing colorectal resection with anastomosis will be enrolled from August 2025 to August 2026. Risk factors will be assessed preoperatively, intraoperatively, and postoperatively. AL will be defined and graded per the International Study Group of Rectal Cancer (ISGRC) criteria.

Key facts

Study ID

NCT07144683

Run by

Minia University

People needed

430

Starts

2025-08-25

Expected to finish

2026-09-25

Last updated by the study team

2026-05-19

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged ≥18 years
• Undergoing elective or emergency colorectal resection with primary anastomosis (e.g., ileocolic, colocolic, colorectal, coloanal)
• Providing written informed consent

You may not qualify if…

• Colorectal resection without anastomosis (e.g., end stoma)
• Inflammatory bowel disease (Crohn's, ulcerative colitis)
• History of previous colorectal surgery involving anastomosis
• Pregnancy
• Unable to provide informed consent or comply with follow-up

Where it is running

• Minia University Hospital — Minya, Minya Governorate, Egypt (enrolling)

Full record on ClinicalTrials.gov

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