Comparison of Milrinone and Epinephrine on TAPSE

Starting soon · Not applicable

Conditions studied: Cardiac Anaesthesia, Cardiopulmonary Bypass

In brief

Cardiopulmonary bypass (CPB) is a critical technology in cardiac surgery, allowing for the temporary replacement of the heart and lung functions during intricate surgical procedures. it has significant post-surgical complications, the most important complications of CPB is right ventricle (RV) dysfunction. Diagnosis and management of RV dysfunction is crucial for maintenance of hemodynamic stability and organ function in early post-operation period and prognostic for later phase.

Key facts

Study ID

NCT07144267

Run by

Mansoura University

People needed

102

Starts

2026-03-01

Expected to finish

2028-03-30

Last updated by the study team

2026-02-25

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• American Society of Anesthesiologists (ASA) physical status II \& III
• Age between 18 and 70 years
• Both Gender
• Body mass index less than 40 kg/m2
• Ejection fraction of >40%
• Tricuspid annular plane systolic excursion (TAPSE) < 1.7cm

You may not qualify if…

• Patient refusal.
• Preoperative RV impairment
• Pulmonary hypertension (estimated pulmonary artery systolic pressure > 50 mmHg)
• Patients with any contraindications to Transesophageal echocardiography (TEE)
• Redo or Re-exploration surgery
• Patients with chronic kidney disease (serum creatinine > 1.5 mg/ dl)
• Patients with chronic liver disease (child pugh B and C)

Full record on ClinicalTrials.gov

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