Exercise and/or HMB in Older Diabetes With Low Muscle Mass

Starting soon · Not applicable · Has a placebo group

Conditions studied: Diabetes, Low Muscle Mass

In brief

The investigators aimed to examine if β-hydroxy-β-methylbutyrate (HMB) supplementation enhances the effects of exercise on muscle mass, physical performance and insulin resistance and observe potential residual effects in older diabetes with low muscle mass, and to find the optimal treatment plan.

Key facts

Study ID

NCT07142941

Run by

Wu Shangling

People needed

120

Starts

2026-04-01

Expected to finish

2027-12-31

Last updated by the study team

2026-03-31

Who can join

Age: 60 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 60-80 ;
• Diagnosis of T2DM
• Low muscle mass: met a reference value for low muscle mass defined by the Asian Working Group for Sarcopenia (AWGS) criteria with skeletal muscle index <5.7 kg/m2 for women and <7.0 kg/m2 for men

You may not qualify if…

• Individuals who had an organic disease of the nervous system;
• Who were restricted from engaging in exercise by a medical doctor;
• Who was unconscious and unable to complete the questionnaire;
• Who used other supplementations for muscle mass gain;
• Who had impaired cardiac, kidney, or liver function.

Full record on ClinicalTrials.gov

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