Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines

Starting soon · Not applicable

Conditions studied: Posttraumatic Osteoarthritis, Anterior Cruciate Ligament (ACL) Rupture

In brief

The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.

Key facts

Study ID

NCT07142369

Run by

Rush University Medical Center

People needed

99

Starts

2026-09-01

Expected to finish

2028-12-01

Last updated by the study team

2026-06-18

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 - 50
• English-speaking
• Clinical evidence of ACL rupture with swelling
• Participant must be undergoing ACL reconstruction surgery

You may not qualify if…

• Age <18 or >50
• Presentation >3 weeks after initial injury
• Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery
• > Kellgren-Lawrence grade 2 changes on preoperative x-ray
• History of hemophilia or inflammatory arthropathy (e.g., rheumatoid arthritis)

Where it is running

• Rush University Medical Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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