Zinc as an Adjunctive Therapy for Cervical Dystonia

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Cervical Dystonia

In brief

The goal of this clinical trial is to evaluate if supplemental zinc can prolong the duration of benefit of botulinum toxin injections in cervical dystonia patients receiving care at the University of Florida. The main aims are: 1. To evaluate the efficacy of zinc citrate supplementation in prolonging the duration of symptom relief provided by botulinum toxin type A (Botox) injections in cervical dystonia patients. 2. To assess the safety and tolerability of zinc supplementation in this patient population. 3. To analyze the potential influence of zinc supplementation on the quality of life and functional outcomes in cervical dystonia patients receiving Botox. Researchers will compare zinc citrate to a placebo (a look-alike substance that contains no active drug) to see if zinc works to extend the effects of Botox. Participants will: Take zinc citrate or a placebo every day for 3 months, then cross over to the alternative treatment for another 3 months. Visit the clinic every 3 months for Botox injections, check ups and surveys.

Key facts

Study ID

NCT07140874

Run by

University of Florida

People needed

25

Starts

2026-06-01

Expected to finish

2027-05-31

Last updated by the study team

2026-05-15

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18-89 years.
• Diagnosed with cervical dystonia.
• Receiving regular BoNT type A (Botox) injections for at least six months.

You may not qualify if…

• Known allergy or intolerance to zinc.
• Significant comorbidities or concurrent medications that could interfere with study outcomes.
• Pregnant or breastfeeding women.
• Already taking a zinc supplement which would exceed tolerable upper intake level in adults (40 mg elemental zinc per day) with addition of zinc study supplement.

Where it is running

• Norman Fixel Institute for Neurological Diseases — Gainesville, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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