Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM)

Recruiting now · Phase 1

Conditions studied: Small Cell Lung Cancer Extensive Stage, Brain Metastases, Solid Tumor, Adult

In brief

To characterize feasibility, safety, and/or preliminary efficacy of personalized strategies to adapt standard radiotherapy treatments to individual patient responses.

Key facts

Study ID

NCT07139990

Run by

University of Texas Southwestern Medical Center

People needed

45

Starts

2025-10-28

Expected to finish

2030-09-01

Last updated by the study team

2025-11-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Cohort A:
• >=18 years old
• Performance status ECOG 0-2
• Extensive stage small cell lung cancer diagnosed by tissue biopsy within 180 days of registration.
• Patient must be planned for or receiving standard of care chemoimmunotherapy.
• Patient must have received no more than 3 cycles by time of study enrollment.
• Able and indicated according to investigator to receive thoracic radiotherapy
• Cohort B:
• 18 years old
• Diagnosis of solid tumor malignancy with MRI-defined brain metastasis lesions (1-5 lesions allowed) within 60 days of registration
• Each brain metastasis lesion enrolled must be 2 - 5 cm, except brainstem lesions which may be 1.5 - 5cm in size.

You may not qualify if…

• Cohort A:
• ⨀ Prior thoracic Radiotherapy
• Cohort B:
• Prior whole brain Radiotherapy
• Prior surgical resection or focal radiotherapy of a target brain metastasis
• Leptomeningeal disease

Where it is running

• Ut Southwestern Medical Center — Dallas, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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