Hemodynamic Effects of Surgical Position in Prone vs. Supine Percutaneous Nephrolithotomy

Recruiting now · Not applicable

Conditions studied: Percutaneous Nephrolithotomy (PCNL), Surgical Positioning, Prone Position, Supine Position, Hemodynamic Stability, Nephrolithiasis

In brief

This prospective, randomized controlled study evaluates the hemodynamic effects of prone and supine positions during percutaneous nephrolithotomy (PNL) for large kidney stones. Surgical position may influence intraoperative and postoperative hemodynamic stability. Prone positioning can increase intrathoracic pressure and reduce venous return, whereas supine positioning may provide greater hemodynamic stability. A total of 84 patients will be randomized to undergo PNL in prone or supine positions. Primary outcomes include changes in hemodynamic parameters during surgery. Results may guide surgical position selection, especially in patients with potential hemodynamic risk.

Key facts

Study ID

NCT07138872

Run by

Gaziosmanpasa Research and Education Hospital

People needed

84

Starts

2025-06-01

Expected to finish

2025-12-30

Last updated by the study team

2025-08-24

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ASA physical status I-III
• Presence of renal calculi indicated for PNL

You may not qualify if…

• Pregnancy
• Uncontrolled coagulopathy
• Previous renal surgery
• Severe cardiac, pulmonary, or neurological disease
• Preoperative urinary tract infection (non-sterile urine culture)
• Surgery duration <60 minutes or >120 minutes
• Preoperative blood transfusion
• Multiple access tracts

Where it is running

• Gaziosmanpaşa Training and Research Hospital — Istanbul, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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