18F-choline Positron-emission-tomography - Computed-tomography Compared to Conventional Imaging for Localizing Diseased Parathyroid Glands in Primary Hyperparathyroidism

Recruiting now · Not applicable

Conditions studied: Primary Hyperparathyroidism

In brief

The goal of this open, single-center, prospective, randomized, clinical study is to compare imaging with \[18F\]fluoromethyl-dimethyl-2-hydroxyethylammonium (18F-choline) positron-emission-tomography - computed-tomography, 18F-ch-PETCT, to conventional imaging with ultrasonography and sestamibi scintigraphy in localizing diseased parathyroid glands in patients diagnosed with primary hyperparathyroidism, pHPT. The question this study aims to answer is: can 18-F-ch-PET-CT more precisely localize diseased parathyroid glands in patients with pHPT before surgery? The objective of the study is to help improve precision in parathyroid surgery, thereby increasing cure rates, minimizing complications, and shortening operation times.

Key facts

Study ID

NCT07138820

Run by

Region Skane

People needed

88

Starts

2023-01-01

Expected to finish

2027-02-28

Last updated by the study team

2025-08-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Proven primary hyperparathyroidism Indication for surgery Adult (>18 years)

You may not qualify if…

• Inability to give informed consent Allergy to contrast Pregnancy and breastfeeding

Where it is running

• Skåne University Hospital — Lund, Sweden (enrolling)

Full record on ClinicalTrials.gov

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