Effect of Acute Grape Seed Extract Supplementation on the Heart Rate Recovery in Young Individuals

Completed · Not applicable · Has a placebo group

Conditions studied: Healthy Young Men

In brief

This study hypothesized that sustained sympathoexcitation via MMA slows down PHRR and that GSE supplementation is effective at improving PHRR in young individuals. 12 Participants were randomly assigned, via a double-blind, cross-over design, to either receive GSE (300mg, 2 capsules) or PL (300mg, 2 capsules), with a washout period of at least 72 hrs. between trials. A submaximal exercise test was performed using a cycle ergometer combined with isometric handgrip exercise using a handgrip dynamometer, and blood flow occlusion by placing a cuff over the brachial artery of the dominant arm. Post heart rate recovery (PHRR) was measured at 5 sec. intervals throughout the experiment. The PHRR was evaluated between GSE and PL at every min. for 300 sec.

Key facts

Study ID

NCT07137988

Run by

California Baptist University

People needed

12

Starts

2024-10-03

Expected to finish

2024-12-31

Last updated by the study team

2025-08-22

Who can join

Age: 18 and older, up to 30. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• good health, nonsmokers, those not taking medications that could affect cardiovascular function

You may not qualify if…

• hypertension, muscular skeletal disorders

Where it is running

• California Baptist University — Riverside, California, United States

Full record on ClinicalTrials.gov

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