A Study of Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet

Recruiting now

Conditions studied: LDL Hyper-responsiveness

In brief

The purpose of this study is to identify whether individuals following a ketogenic diet who experience extreme LDL-C elevation, termed "hyper-responders", have identifiable genetic variations in genes involved in cholesterol absorption.

Key facts

Study ID

NCT07137286

Run by

Mayo Clinic

People needed

100

Starts

2025-09-11

Expected to finish

2027-08-01

Last updated by the study team

2025-11-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• LDL-C >170 mg/dL in response to starting a ketogenic diet

You may not qualify if…

• Patients who do not consent to blood draw for genetic testing
• Those with LDL-C <170 mg/dL on a ketogenic diet

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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