Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology

Recruiting now · Not applicable

Conditions studied: Neuromuscular Diseases, Obesity (Disorder), Myotonic Dystrophy 1, Myasthenic Syndrome, Charcot Marie Tooth Disease (CMT), Glycogen Storage Disease Type II Pompe Disease, Facio-Scapulo-Humeral Dystrophy, Myasthenia Gravis, Huntington Disease, Progressive Supranuclear Palsy (PSP), Hereditary Spastic Paraplegia, Ataxia, Spinocerebellar

In brief

The ActiLiège-Adult study is a prospective, longitudinal, observational study designed to collect natural history data on adult patients with neurological or metabolic diseases affecting movement. Conducted at the Centre de Référence Liégeois des Maladies Neuromusculaires in Liège, Belgium, the study will enroll 300 ambulant patients, including individuals with neuromuscular disorders and obesity. Using the Syde® wearable device, the study aims to continuously monitor motor function in real-life settings over a period of up to two years. The primary objective is to evaluate the utility of digital mobility outcomes, such as the 95th centile of stride velocity (SV95C), as reliable and objective endpoints for future clinical trials.

Key facts

Study ID

NCT07136844

Run by

Centre Hospitalier Universitaire de Liege

People needed

300

Starts

2024-03-29

Expected to finish

2030-12-01

Last updated by the study team

2025-08-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ambulant patients (i.e. able to walk 10 meters without assistance)
• Confirmed diagnosis by the investigator based on current gold standard in his/her disease (genetic testing, clinical criteria, etc.)
• Myotonic dystrophy type 1 (DM1) and Charcot-Marie-Tooth (CMT) patients should present sensitive of motor signs on physical examination.
• Myasthenic patients should be seropositive, and Myasthenia Gravis Foundation of America (MGFA) class II to IV.
• Patient with morbid obesity (Body Mass Index> or = 35 at inclusion visit).
• Signed informed consent form by patient him/herself and patient willing and able to comply with all study procedures.

You may not qualify if…

• Non-ambulant patients
• Patients with extreme cognitive disorders that limit their understanding of the exercises to be performed
• Patients who have undergone a surgical procedure or who have experienced recent trauma (within fewer than 6 months) affecting the upper or lower limbs
• A concomitant chronic or acute neurological, endocrine, infectious, allergic, or inflammatory pathology within the 3-week period immediately prior to inclusion
• Patients who are participating in an interventional clinical trial
• Pregnant or breastfeeding women

Where it is running

• Centre de référence des maladies neuromusculaire, Centre Hospitalier Régional de la Citadelle — Liège, Belgium (enrolling)

Full record on ClinicalTrials.gov

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