Sciatic Nerve Stiffness Using Two-Sequences of Lower Limb Neurodynamic Testing: A Shear Wave Elastography Study

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Conditions studied: Sciatic Nerve

In brief

The purposes of the study are: 1. To measure differences in Sciatic nerve (SN) stiffness using shear-wave elastography (SWE) during two movement sequences of the lower limb neurodynamic test (LLNT) in low back pain with sciatica. 2. To measure differences in Sciatic nerve stiffness using shear-wave elastography during two movement sequences of the lower limb neurodynamic test in control group. 3. To compare difference in Sciatic nerve stiffness using shear-wave elastography during two movement sequences of the lower limb neurodynamic test between low back pain patients with sciatica and control group.

Key facts

Study ID

NCT07136441

Run by

Cairo University

People needed

60

Starts

2025-08-15

Expected to finish

2026-02-28

Last updated by the study team

2025-09-11

Who can join

Age: 25 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Thirty participants ranging in age from 25 to 40 years from both genders with a diagnosis of low back pain with radiating leg pain and thirty control group.
• The main symptoms are low back pain with unilateral leg pain(sciatica) for 3-12 months for group A.
• Patients with lumbar disc herniation (L4-5) with diagnostic imaging as MRI for group A.
• Positive straight leg raising are considered for inclusion in the study for group A.
• Control group must be free from any symptoms of nerve irritation or compression, with normal neurological examination findings, including reflexes, sensation, negative straight leg raising and motor strength.

You may not qualify if…

• Diabetes mellitus.
• Any type of polyneuropathy
• Trauma of lumbar spine
• Previous history of back surgery
• Piriformis syndrome.
• Participants with conditions that reduce image quality on US imaging (thick gluteal subcutaneous fat tissue.
• Hip joint prosthesis.
• Professional athletes (Neto et al., 2024).
• Skin infection

Where it is running

• Cairo University — Giza, Egypt (enrolling)

Full record on ClinicalTrials.gov

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