OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Cardiovascular Disease

In brief

The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).

Key facts

Study ID

NCT07136012

Run by

Amgen

People needed

11000

Starts

2025-08-22

Expected to finish

2031-10-20

Last updated by the study team

2026-08-07

Who can join

Age: 50 and older, up to 105. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥50 years
• Lp(a)≥ 200 nmol/L during screening
• Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis

You may not qualify if…

• Prior acute atherothrombotic event (myocardial infarction, stroke, transient ischemic attack, acute limb ischemia)
• Prior or planned arterial revascularization
• History of major bleeding disorder

Where it is running

• University of Alabama Birmingham Saint Vincents Birmingham — Birmingham, Alabama, United States (enrolling)
• Birmingham Clinical Research — Birmingham, Alabama, United States (enrolling)
• Alliance For Multispecialty Research - Daphne — Daphne, Alabama, United States (enrolling)
• Eastern Shore Research Institute — Fairhope, Alabama, United States (enrolling)
• Heart Center Research LLC — Huntsville, Alabama, United States (enrolling)
• CB Flock Research Corporation — Mobile, Alabama, United States (enrolling)
• Phoenix Clinical — Phoenix, Arizona, United States (enrolling)
• Elite Clinical Studies LLC — Phoenix, Arizona, United States (enrolling)
• Hero Clinical Research — Phoenix, Arizona, United States (enrolling)
• HonorHealth Research Institute — Scottsdale, Arizona, United States (enrolling)
• Eclipse Clinical Research — Tucson, Arizona, United States (enrolling)
• Lynn Institute of the Ozarks — Little Rock, Arkansas, United States (enrolling)
• National Heart Institute — Beverly Hills, California, United States (enrolling)
• 310 Clinical Research — Inglewood, California, United States (enrolling)
• University of California San Diego — La Jolla, California, United States (enrolling)
• InvivoCure — Los Angeles, California, United States (enrolling)
• Valley Clinical Trials — Northridge, California, United States (enrolling)
• Clinical Trials Research - Sacramento — Roseville, California, United States (enrolling)
• Alliance Clinical Research — San Diego, California, United States (enrolling)
• Encompass Clinical Research — Spring Valley, California, United States (enrolling)
• Stanford Health Care — Stanford, California, United States (enrolling)
• Manshadi Heart Institute — Stockton, California, United States (enrolling)
• Blue Coast Cardiology — Vista, California, United States (enrolling)
• Diablo Clinical Research — Walnut Creek, California, United States (enrolling)
• Advanced Cardiovascular LLC — Alexander City, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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