Sleeve Lobectomy Following Neoadjuvant Therapy in NSCLC

Recruiting now

Conditions studied: Lung Cancer, Neoadjuvant Therapy

In brief

The goal of this observational, retrospective, multicenter cohort study is to evaluate the surgical and oncologic outcomes of sleeve lobectomy performed via minimally invasive (RATS/VATS) or open thoracotomy approaches in patients with non-small cell lung cancer (NSCLC) who have undergone neoadjuvant therapy, including chemotherapy, immunotherapy, or combination regimens. The main questions this study aims to answer are: * Does minimally invasive sleeve lobectomy result in comparable or improved perioperative and postoperative outcomes compared to open thoracotomy following neoadjuvant treatment in NSCLC? * Does surgical approach influence oncologic endpoints such as margin status, lymph node dissection, recurrence-free survival, and overall survival? This research addresses a critical gap in the thoracic oncology field by evaluating the safety, complexity, and efficacy of advanced surgical techniques in the context of evolving multimodal therapy paradigm. Findings may inform clinical decision-making and optimize patient selection in an era of increasing use of neoadjuvant strategies for resectable NSCLC.

Key facts

Study ID

NCT07135856

Run by

Shanghai Chest Hospital

People needed

400

Starts

2025-09-01

Expected to finish

2026-12-01

Last updated by the study team

2025-12-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Histologically confirmed NSCLC
• Undergoing sleeve lobectomy with curative intent
• Receipt of neoadjuvant therapy (chemotherapy, immunotherapy, target therapy, etc.)
• Surgical approach: either minimally invasive (VATS or RATS) or open thoracotomy
• Availability of complete perioperative and follow-up data (minimum 12-month follow-up or until death)
• Signed informative consent

You may not qualify if…

• Sublobar resections (e.g., segmentectomy) or pneumonectomy
• Absence of neoadjuvant therapy
• Purely diagnostic surgical procedures
• Incomplete medical records or lost to follow-up
• Metastatic (stage IV) disease at time of surgery

Where it is running

• Shanghai Chest Hospital — Shanghai, Shanghai Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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