Incidence of Postoperative Cognitive Decline in Patients With Preexisting Cognitive Impairment
Recruiting now
Conditions studied: Cognitive and Behavioral Impairment
In brief
This study aims to find out how often memory and thinking problems happen after surgery in people who already have memory issues before their operation. These memory problems are called postoperative cognitive decline (POCD). Older adults with memory problems before surgery may be more likely to have trouble with thinking, memory, and daily activities after their operation. This study will follow patients who already have memory problems before surgery and see how their thinking and memory change after surgery. The results will help doctors better understand how to care for these patients before, during, and after surgery.
Key facts
- Study ID
- NCT07135336
- Run by
- Peking University Shenzhen Hospital
- People needed
- 340
- Starts
- 2025-07-15
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2025-08-22
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age ≥ 60 years
- Preoperative screening with MMSE and MoCA-B indicating mild cognitive impairment (MCI) or mild dementia
- Undergoing elective non-cardiac surgery under general anesthesia
You may not qualify if…
- Expected difficulty in completing neuropsychological assessments (e.g., inability to communicate in Mandarin, blindness, or deafness)
- Usual residence outside Shenzhen
- Normative Reference Group
- Inclusion Criteria:
- Age ≥ 60 years
- No history of general anesthesia surgery within the past 12 months
- Mini-Cog score > 1
- Exclusion Criteria:
- Planned elective surgery under general anesthesia within the next 12 months
- History of suspected or diagnosed cognitive impairment, or screening indicating cognitive impairment using MMSE and MoCA-B
- Expected difficulty in completing neuropsychological assessments (e.g., inability to communicate in Mandarin, blindness, or deafness)
- Usual residence outside Shenzhen
Where it is running
- Peking University Shenzhen Hospital — Shenzhen, Guangdong, China (enrolling)
Full record on ClinicalTrials.gov
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