The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults: A Longitudinal Study

Recruiting now

Conditions studied: Chronic Non-Specific Low Back Pain, Cognitive Decline, Longitudinal Study, Older Adults, Brain Imaging

In brief

Chronic non-specific low back pain (CNSLBP) is a common condition among older adults and has been associated with an increased risk of executive function impairment. Research shows that older adults experiencing chronic pain are more likely to show worse cognitive performance compared to healthy individuals. While there is a bidirectional relationship between pain and executive functions, cognitive performance especially for some executive functions (e.g. inhibition, switching, working memory) is crucial for managing pain in older adults. Furthermore, executive dysfunctions are associated with decline in functional status among the population, particularly in performing instrumental activities in daily living. Therefore, maintaining executive function emerges as a pivotal consideration for older adults with CNSLBP. Studies provide preliminary evidence that connects brain changes with chronic pain and cognitive functions. For instance, multisite chronic pain may increase the risk of cognitive decline through structural changes like hippocampal atrophy. Besides, functional brain changes in chronic pain may reduce deactivation several key default mode network regions, predisposing individuals to cognitive impairments. Despite the aforementioned brain changes, no direct evidence supports the hypothesis that structural and functional brain changes caused by CNSLBP in older adults may be associated with cognitive decline. It remains unclear that whether structural changes (e.g. reduced hippocampal, cerebellar gray matter, white matter volume in the right frontal region) and/or functional changes (e.g. deactivation of default mode network regions, heightened activation in the anterior cingulate cortex) cause by CNSLBP are associated with cognitive decline. With neuroimaging techniques, brain mechanisms connecting CNSLBP and executive function deficits can be explained. To deepen understanding of the brain mechanisms underlying executive function decline in older adults with CNSLBP, this study will directly compare pain intensity, executive functions, brain structure, and functional changes of the brain between older adults with CNSLBP and age-matched healthy controls. A longitudinal approach is established to quantify the relationship between CNSLBP-related brain changes and executive functions in older adults, providing insights into the development of new treatment strategies to improve or prevent executive function decline in older adults with CNSLBP.

Key facts

Study ID: NCT07134699
Run by: The Hong Kong Polytechnic University
People needed: 60
Starts: 2025-05-06
Expected to finish: 2026-08-31
Last updated by the study team: 2025-08-21

Who can join

Age: 60 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Older adults with and without chronic non-specific low back pain (CNSLBP) aged between 60 and 85 years
Having normal cognitive function (Hong Kong Montreal Cognitive Assessment ≥ 26)13
Right-handed
Cantonese speaking
Having at least 6 years of formal education and know how to read and write Chinese
Agreeing to sign an informed consent form
Being able to communicate via email or text message because several study measures will be collected electronically.

You may not qualify if…

Inability to ambulate without assistance from another person (canes or walkers will be allowed)
Having specific causes of LBP (e.g., spinal stenosis, lumbar disc herniation, spondylolisthesis, recent vertebral fracture, spinal infection)
Having other concurrent musculoskeletal conditions at other body parts (e.g., fibromyalgia, or neck or knee pain)
Self-reported history of lumbar or lower extremity surgery
Self-reported history of neurological or psychiatric disorders (e.g., stroke, brain surgery, head trauma; schizophrenia, multiple personality disorder, dissociative identity disorder, stroke) or self-reported cancer history
Self-reported specific inflammatory disorder: rheumatoid arthritis, rheumatica, scleroderma, lupus, or polymyositis
Unexplained, unintended weight loss of 20 lbs or more in the past year
Cauda equina syndrome
Uncorrected visual deficit
Drug or alcohol addiction
Taking alcohol, opioids or benzodiazepines medicines 24 hours before the experiment
Claustrophobia
Contraindications for undergoing the magnetic resonance imaging (MRI) examination based on the MRI safety screening form of University Research Facility in Behavioral and Systems Neuroscience at The Hong Kong Polytechnic University

Where it is running

Department of Rehabilitation Sciences — Hong Kong, Hong Kong (enrolling)

Full record on ClinicalTrials.gov

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