Target Organ Damage in Patients With Repaired Coarctation of Aorta and Exercise Induced Hypertension
Enrolling by invitation
Conditions studied: Coarctation of the Aorta
In brief
The goal of this observational study is to obtain data on the effect of exercise induced hypertension on target organs in adult patients with repaired coarctation of the aorta. The main questions it aims to answer are: * patients with exercise induced hypertension have signs of hypertensive heart disease? * patients with exercise induced hypertension have increased arterial stiffness? * patients with exercise induced hypertension have signs of hypertensive renal damage? Participants will be invited for an outpatient appointment during which medical history and physical investigation will be performed. They will undergo cardiopulmonary exercise testing during which blood pressure will be measured regularly. Transthoracic echocardiography will also be performed as well as assessment of arterial stiffness by measuring pulse wave velocity. Renal function will be assessed by blood and urine analysis.
Key facts
- Study ID
- NCT07134621
- Run by
- University Medical Centre Ljubljana
- People needed
- 50
- Starts
- 2025-07-16
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2026-04-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- adult patients aged 18 years and older
- history of coarctation of aorta repair
You may not qualify if…
- haemodynamically significant recoarctation
- arterial hypertension at rest
- antihypertensive therapy
- associated haemodynamically significant valvular heart disease
- associated complex congenital heart disease
- advanced heart failure
- symptomatic arrhythmias
- cognitive or physical limitations to perform exercise stress testing
Where it is running
- UMC Ljubljana — Ljubljana, Slovenia
Full record on ClinicalTrials.gov
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