The Impact of Perineural Injection Therapy for Adhesive Capsulitis.

Recruiting now · Not applicable

Conditions studied: Adhesive Capsulitis

In brief

The goal of this clinical trial is to learn if Perineural Injection Therapy (PIT) works to treat adhesive capsulitis (frozen shoulder) in adults. It will also learn about the safety of PIT. The main questions it aims to answer are: Does PIT reduce shoulder pain and improve shoulder range of motion more effectively than conventional therapy alone? What side effects or medical problems do participants experience when receiving PIT? Researchers will compare PIT to conventional therapy to see if PIT works better to treat adhesive capsulitis. Participants will: Receive either: PIT once weekly for 6 weeks plus physiotherapy and oral analgesics (excluding NSAIDs), or Conventional therapy only (physiotherapy and analgesics including NSAIDs) Attend scheduled follow-up visits at Week 6, 1 month, and 3 months after treatment Perform daily home-based shoulder exercises and record their analgesic use and any side effects in a patient diary

Key facts

Study ID: NCT07134010
Run by: Universiti Teknologi Mara
People needed: 24
Starts: 2025-06-03
Expected to finish: 2026-06-01
Last updated by the study team: 2025-09-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age 18 and above.
Diagnosed with primary adhesive capsulitis by a specialist.
Limitation of range of motion ≥ 50% relative to the normal side or normal reference (in patient with bilateral adhesive capsulitis) in three or more movement directions (i.e., external rotation, abduction, forward flexion, and internal rotation).
Chronic adhesive capsulitis shoulder pain lasting for at least 3 months.
Pain score of at least 4/10 on the Numerical Rating Scale (NRS) during movement, indicating at least moderate pain severity.
Consented to the study.

You may not qualify if…

Received any shoulder pain injection within the past 6 weeks or surgical intervention such manipulation under anesthesia, arthroscopic capsular release, or open surgery for capsular release.
Diagnosed with other shoulder pathology such as neurologic deficits affecting shoulder function, tumour, rotator cuff injury or fracture.
Has history of allergy to dextrose solution.
Patients receiving steroidsimmunosuppressants, psychotropic medication, or other medications that may affect, the clinical outcomes
Patients with haemorrhagic disease, taking anticoagulant drugs, or patients with severe diabetes mellitus having an increased risk of infection (HBA1c >8%)
Do not understand Malay or English language.
Unable to follow a 3 steps command.

Where it is running

Hospital Al-Sultan Abdullah, UiTM Puncak Alam — Kuala Selangor, Selangor, Malaysia (enrolling)

Full record on ClinicalTrials.gov

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