Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Drain Output After Breast Reduction Surgery, Breast Reductions

In brief

This study aims to evaluate whether tranexamic acid (TXA), a medication that helps reduce bleeding, can decrease fluid drainage after breast reduction surgery. Participants will be randomly assigned to receive either intravenous TXA or no TXA during surgery. Additionally, one breast will receive TXA through the surgical drain, while the other will receive saline. This approach allows to compare the effects of TXA on fluid buildup and healing. The goal is to improve recovery and reduce complications after breast reduction surgery.

Key facts

Study ID: NCT07131592
Run by: Massachusetts General Hospital
People needed: 160
Starts: 2025-11-18
Expected to finish: 2027-08-31
Last updated by the study team: 2026-01-16

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Adults aged 18 years or older
Elective bilateral breast reduction
Patient understands and is willing to participate in the study
Patient willing to and capable of providing informed consent

You may not qualify if…

Age less than 18 years old
Prior radiation to the breast
Secondary/Revision breast reduction
Known coagulopathy or bleeding disorders
Intraoperative coagulopathy
History of seizures
Active smokers
Allergy or contraindication to TXA
Pregnant or breastfeeding patients
Patient is unable or unwilling to complete the anticipated study follow-up
Inability to understand the aims and objectives of the study
Inability to or unwilling to provide informed consent

Where it is running

Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.