Intravenous Regional Analgesia of Dexmedetomidine

Enrolling by invitation · Not applicable · Has a placebo group

Conditions studied: Dexmedetomidine Analgesia, Knee Surgery

In brief

Dexmedetomidine is a highly selective α₂-adrenergic receptor agonist that exerts its effects by inhibiting the release of norepinephrine at presynaptic nerve terminals, leading to reduced sympathetic activity; This mechanism results in analgesia, sedation, and anxiolysis without significant respiratory depression

Key facts

Study ID

NCT07131579

Run by

Mansoura University

People needed

100

Starts

2026-01-12

Expected to finish

2027-08-30

Last updated by the study team

2026-01-21

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-60 years
• American Society of Anesthesiologists (ASA) Physical Status Classification System I or II
• Scheduled for elective knee surgery under spinal anesthesia
• Body mass index (BMI) 18-30 kg/m²
• Able to provide informed consent

You may not qualify if…

• Pregnant or lactating women
• Hypersensitivity to dexmedetomidine
• Chronic kidney diseases serum creatinine >1.5 mg\\dl or Patient has known renal disease
• Chronic opioid or sedative use
• Any cardiac conduction abnormalities
• Uncontrolled arterial hypertension
• Neuropathy
• Diabetes mellitus
• Impaired perfusion of the operative limb (Edema, Peripheral vascular Disease e.g "Raynaud Phenomenon")
• History or recent lower limb deep venous thrombosis (DVT) or Phlebitis
• Infection or vascular access limitation in the operated lower limbs
• Any contraindication of spinal anesthesia e.g "Coagulopathy"
• Any contraindications for tourniquet e.g "sickle cell anemia"

Where it is running

• Faculty of Medicine-Mansoura University — Al Mansurah, Egypt

Full record on ClinicalTrials.gov

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