Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure

Recruiting now · Phase 2

Conditions studied: Blast Injury

In brief

This is a 4-year, longitudinal study of 100 active-duty Navy SEALs. The goal of the study is to determine whether repeated blast exposure affects SEAL brain health and to develop an initial diagnostic testing protocol that detects repeated blast brain injury.

Key facts

Study ID

NCT07131475

Run by

Massachusetts General Hospital

People needed

100

Starts

2025-10-14

Expected to finish

2029-08-31

Last updated by the study team

2025-10-31

Who can join

Age: 18 and older, up to 50. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Active-duty Navy SEAL Service Member
• Early career SEAL (0-2 years) or mid-late career SEAL (10-15 years)
• Age 18-50 years
• Males, regardless of race or ethnicity

You may not qualify if…

• History of moderate or severe TBI
• History of major neurological disorder
• Untreated or unstable severe psychiatric condition
• Current severe medical condition that requires long-term treatment
• Any condition that may cause undue risk to the participant or create a logistical contraindication
• MRI contraindication
• PET contraindication

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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