Brain NAD in Alzheimer's Disease

Recruiting now

Conditions studied: Alzheimer Disease (AD)

In brief

The goal of this observational study is to learn about the levels of nicotinamide adenine dinucleotide (NAD) in the brains of people with Alzheimer's disease. The study aims to determine if brain NAD levels are lower in people with Alzheimer's disease compared with people of the same age group who do not have Alzheimer's disease. Participants with or without Alzheimer's disease will have a brain imaging session where NAD will be measured using magnetic resonance spectroscopy (MRS). Eight months later, they will have a second, similar, brain imaging session.

Key facts

Study ID

NCT07127510

Run by

Florida Atlantic University

People needed

20

Starts

2026-03-18

Expected to finish

2027-06-01

Last updated by the study team

2026-03-24

Who can join

Age: 65 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants are able to come to the Florida Atlantic University Clinical Research Unit, are verbal and ambulatory.
• Age 65 to 80 included.
• People with Alzheimer's disease (AD): AD diagnosis established by the person's physician according to the following criteria: clinical diagnosis AND either positive amyloid PET-scan or FDA-approved positive CSF or blood test.

You may not qualify if…

• Under the age of 65 or over the age of 80.
• Advanced dementia such that the person would require sedation for undergoing an MRI scan.
• Receiving anti-amyloid intravenous treatments Leqembi or Kinsula.
• Having an MRI-incompatible pacemaker or other MRI-incompatible hardware (e.g. comprising a metallic part).
• Having a history of seizures.
• Working at night.
• Having cancer or having been diagnosed with cancer within the last 5 years (excluding superficial squameous or basal cell cancer).
• People with no AD: MoCA test result lower than 26.

Where it is running

• FAU Clinical Research Unit — Boca Raton, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.