The Impact of GLP Medication on Colonoscopy Bowel Preparation Quality
Recruiting now · Phase 4
Conditions studied: GLP - 1, Bowel Preparation for Colonoscopy
In brief
The goal of this clinical trial is to learn how GLP-1 and GIP agonists effect bowel preparation in patients scheduled for colonoscopies. The main questions it aims to answer are: * Does GLP-1 and GIP agonist increase the rate of inadequate bowel preparation? * Does the quality of bowel preparation differ in patients who hold vs. those who continue a single dose of their GLP-1 or GIP agonist medication? * Are there any differences in the rates of complications gastric aspiration in patients who hold vs. continue a single dose of their GLP-1 or GIP agonist medication?
Key facts
- Study ID
- NCT07127354
- Run by
- The Cleveland Clinic
- People needed
- 132
- Starts
- 2025-08-01
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2025-12-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adult patient (Age 18 years or older)
- Patient scheduled for outpatient screening, surveillance, or diagnostic colonoscopy
- Using a GLP-1 or GIP agonist at a stable dose for at least one month
You may not qualify if…
- Unable to provide informed consent, e.g., dementia
- Patient refuses the USMSTF recommended bowel cleansing regimen for patients with diabetes or obesity (split-dose 4 liters polyethylene glycol + 15 mg bisacodyl the afternoon before; low residue diet 3 days before colonoscopy; clear liquid diet the day before colonoscopy)
- Risk factors for inadequate bowel preparation besides diabetes and obesity with a likelihood ratio of 1.6 or greater:
- Cirrhosis
- Parkinson's disease
- Dementia
- Tricyclic antidepressant use
- Opioid use
- Gastroparesis* or suspected gastric outlet obstruction on pre-procedure imaging (*defined based on a documented 4-hour solid phase gastric emptying study or prior history of retained gastric contents during upper endoscopy)
- Previous colorectal surgery
- Prior history of inadequate bowel preparation
Where it is running
- Cleveland Clinic — Cleveland, Florida, United States (enrolling)
- Cleveland Clinic — Cleveland, Florida, United States (enrolling)
- Cleveland Clinic Weston — Weston, Florida, United States (enrolling)
Full record on ClinicalTrials.gov
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