Disease Severity, Mortality Risk, and Muscle Function in Intensive Care Unit Patients

Recruiting now

Conditions studied: Critically Ill Patients

In brief

Intensive Care Units are specialized, technologically advanced hospital units that provide continuous monitoring and care from multiple healthcare disciplines for patients who are critically ill and face a high risk of death or serious health problems. Prolonged periods of immobility, which are common during treatment in these units, can cause serious complications such as muscle weakness, decline in physical function, and a lower quality of life. There are scoring systems designed to predict the severity of a patient's illness and their likely outcomes, such as the scoring system called the Acute Physiology and Chronic Health Evaluation version two. However, these scoring systems are not yet widely used as a regular part of patient care. Although weakness and wasting of muscles away from the center of the body are known to affect the recovery process of patients who survive intensive care treatment, the connection between how severe the illness is and the strength of the muscles used for breathing, the structure of peripheral muscles, and their biomechanical characteristics is still not fully understood. This study aims to explore these relationships to help improve physiotherapy and rehabilitation treatments for patients in intensive care.

Key facts

Study ID

NCT07124442

Run by

Istinye University

People needed

45

Starts

2025-08-15

Expected to finish

2025-10-30

Last updated by the study team

2025-08-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Not dependent on mechanical ventilation,
• Patient or legal representative provides consent to participate,
• Aged 18 years or older,
• Monitored in the ICU for at least 48 hours.

You may not qualify if…

• Unable to obtain ethical consent,
• Presence of neuromuscular disease affecting muscle tone,
• Patients unable to cooperate during measurement due to impaired consciousness, communication disorder, or other medical reasons,
• Presence of infection, open wound, or any lesion impairing skin integrity at the anatomical measurement site.

Where it is running

• Istinye University Bahçeşehir Liv University Hospital — Istanbul, Esenyurt, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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