Alpha-Blockers Prior to Ureteral Access Sheath Placement in Flexible Ureteroscopy: A Randomized Prospective Study

Recruiting now · Phase 4

Conditions studied: Nephrolithiasis, Alpha Blocker, Ureteral Access Sheath

In brief

This study aims to evaluate whether the use of alpha-blockers before flexible ureterorenolithotripsy facilitates the passage of the ureteral access sheath. The trial will enroll adult patients diagnosed with kidney stones who are scheduled for flexible ureteroscopy. Participants will be randomly assigned to receive or not receive alpha-blockers for seven days before surgery. The primary outcome is the rate of successful sheath placement without the need for a second procedure. Secondary outcomes include the incidence of ureteral injuries and the need for additional surgical interventions. The goal is to improve surgical efficiency and patient outcomes in the treatment of kidney stones.

Key facts

Study ID

NCT07124299

Run by

Pedro de Figueiredo Buchalla

People needed

140

Starts

2024-01-01

Expected to finish

2026-02-01

Last updated by the study team

2025-08-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Diagnosis of nephrolithiasis with surgical indication for flexible ureterorenolithotripsy
• Ability to provide written informed consent

You may not qualify if…

• Age < 18 years
• Pregnancy
• History of ureteral stricture, prior ureteral reconstructive surgery, and/or abdominal or pelvic radiotherapy
• Prior ureteroscopy or ipsilateral double-J stent placement within the past 3 months
• Chronic use of alpha-blockers for benign prostatic hyperplasia or medical expulsive therapy for ureteral stones

Where it is running

• Centro Universitário FMABC — Santo André, São Paulo, Brazil (enrolling)

Full record on ClinicalTrials.gov

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