Neurofeedback to Reduce Spontaneous Recovery of Threat Expectancy

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Healthy

In brief

This study tests the efficacy of a new behavioral intervention with the goal of reducing spontaneous recovery of threat expectancy in healthy adults. This real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention delivers feedback based on a functional connection between the prefrontal cortex and the hippocampus.

Key facts

Study ID: NCT07122739
Run by: Trustees of Princeton University
People needed: 40
Starts: 2025-07-17
Expected to finish: 2028-06-01
Last updated by the study team: 2026-02-23

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Adults aged 18-50
No history of psychiatric disorders or neurological disorders affecting the central nervous system.
Are not currently taking psychoactive medication or drugs of abuse.
Must be eligible to enter an MRI (i.e., no permanent metal or medical implants)
Normal color vision
Right-handed
Full reading and writing English comprehension
Must exhibit spontaneous recovery behavior as determined by an experimenter in a prescreening experimental session
Must be able to provide informed consent

You may not qualify if…

Pregnancy (female participants)
Outside of age range
History of psychiatric or neurological disease
Currently taking psychoactive medication or drugs of abuse
Color blindness
Primary left-handedness
Less than full reading and writing English comprehension
Do not exhibit spontaneous recovery behavior as determined by an experimenter in a prescreening experimental session
Refusing to provide informed consent

Where it is running

Princeton Neuroscience Institute — Princeton, New Jersey, United States (enrolling)

Full record on ClinicalTrials.gov

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