EVALUATION OF SALIVA AS LIQUID BIOPSY FOR EARLY DETECTION OF ORAL CANCER IN PATIENTS WITH ORAL-SUBMUCOUS FIBROSIS (OSMF)

Recruiting now

Conditions studied: The Study Focuses on the Saliva as Potential Source of Early Detection of Oral Cancer

In brief

Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing. Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.

Key facts

Study ID

NCT07122128

Run by

Liaquat University of Medical & Health Sciences

People needed

1000

Starts

2021-06-01

Expected to finish

2026-06-30

Last updated by the study team

2025-08-14

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy volunteers
• patients with oral submucous fibrosis
• patients with biopsy proven oral cancer

You may not qualify if…

• patients with oral infection

Where it is running

• Medical Research Center — Jāmshoro, Sinch, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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