Probenecid Administration for Alcohol Craving and Consumption

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Alcohol Use Disorder (AUD), Alcohol Consumption, Craving

In brief

This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g /day) compared to placebo in individuals with AUD to test if reduces craving and alcohol consumption.

Key facts

Study ID

NCT07118618

Run by

Brown University

People needed

120

Starts

2026-03-14

Expected to finish

2030-12-31

Last updated by the study team

2026-03-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• • Male or female, ≥18 years.
• women >7 drinks/week; men >14 drinks/week.
• meet moderate to severe AUD score for DSM-5 criteria.
• Breath Alcohol Content (BrAC)=0.00 at each visit.
• in good health as confirmed by medical history, physical examination and lab tests.
• willing to adhere to the study procedures.
• understand informed consent and questionnaires in English at an 8th grade level.

You may not qualify if…

• • Women who are breastfeeding or positive urine test for pregnancy.
• clinically significant medical abnormalities: unstable hypertension, clinically significant abnormal EKG, bilirubin >150% of the upper normal limit, ALT/AST >300% the UNL, creatinine clearance ≤60 dl/min
• meet DSM-5 criteria for a diagnosis of schizophrenia, bipolar disorder, or other psychoses
• medications that reduce alcohol consumption (naltrexone, disulfiram).
• use aspirin (salicylates may reduce effect of probenecid), penicillin, methotrexate (may increase concentration).
• history of suicide attempts in the last three years.
• current diagnosis of a moderate or severe cannabis use disorder as assessed by self-report, SCID-E for SUD, and urine toxicology screen at baseline.
• current diagnosis of another substance disorder at any severity, other than nicotine, as assessed by self-report, SCID-E for SUD, and urine toxicology screen at baseline.
• current use of medications that may interact with probenecid.
• history of hypersensitivity to sulfa drugs.

Where it is running

• Brown University — Providence, Rhode Island, United States (enrolling)

Full record on ClinicalTrials.gov

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