Ultrasonographic Assessment of Muscle Morphology, Function, and Clinical Findings in Spastic Cerebral Palsy

Recruiting now

Conditions studied: Muscle Spasticity, Gait Disorders, Neurologic, Cerebral Palsy, Spastic

In brief

This study focuses on children with spastic cerebral palsy and aims to examine how muscle morphology and tissue characteristics, as assessed by ultrasound, may relate to functional motor abilities. It is designed as a prospective, cross-sectional, observational study. Planned ultrasound-based assessments include parameters such as muscle thickness, pennation angle, fascicle length, echo intensity, tissue stiffness (via shear wave elastography), and microvascular flow (via superb microvascular imaging). These measurements are intended to be compared with standard clinical evaluations, including the GMFCS, GMFM-66, MAS, MACS, and Tardieu Scale. The study seeks to contribute to a better understanding of the relationship between muscle architecture and functional outcomes, with the goal of generating insights that may inform individualized rehabilitation planning.

Key facts

Study ID

NCT07118228

Run by

Kocaeli University

People needed

36

Starts

2025-12-15

Expected to finish

2026-06-30

Last updated by the study team

2026-02-03

Who can join

Age: 4 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of spastic cerebral palsy (SCP) according to the criteria defined by Rosenbaum et al. (2007)
• Age between 4 and 18 years
• Gross Motor Function Classification System (GMFCS) Level I, II, or III
• Manual Ability Classification System (MACS) Level I, II, III, or IV

You may not qualify if…

• Non-spastic types of cerebral palsy (e.g., dyskinetic, ataxic)
• Diagnosis of neuromuscular disorders other than cerebral palsy (e.g., hereditary neuropathy, myopathy)
• Presence of muscle contractures or fixed deformities in the limbs selected for ultrasound and clinical assessment
• Cognitive or behavioral impairments that prevent cooperation during ultrasound or clinical evaluation
• Botulinum toxin-A (BoNT-A) injection applied to the target muscles within the last 6 months
• Current treatment with oral or intrathecal antispastic medications
• History of orthopedic surgery or selective dorsal rhizotomy involving the target muscles
• Acute infection, febrile illness, or severe systemic disease (e.g., advanced heart failure, respiratory insufficiency) that may compromise the safety of assessments

Where it is running

• Kocaeli University Faculty of Medicine — Kocaeli, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.