A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics for a Single Dose of HRS-9821 Powder for Inhalation and Inhalation Suspension Administered in Healthy Subjects and Multiple Doses in Patients With COPD.

Recruiting now · Phase 1 · Has a placebo group

Conditions studied: COPD

In brief

The aim of this study was to evaluate the safety and tolerability of HRS-9821 Powder for Inhalation and inhalation suspension administered in a single dose in healthy individuals and multiple doses in patients with COPD

Key facts

Study ID

NCT07116915

Run by

Guangdong Hengrui Pharmaceutical Co., Ltd

People needed

160

Starts

2025-08-11

Expected to finish

2026-12-01

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Informed consent was obtained to participate in the trial
• Body weight ≥45 kg, BMI 18-33 kg/m2 (both ends included)
• The 12-lead ECG was normal or abnormal but clinically insignificant until randomization
• Contraception was strict from the time informed consent was signed until 1 month (for subjects receiving HRS-9821/ placebo) or 3 months (for male subjects receiving moxifloxacin) after the last dose
• All study regulations and procedures were followed and inhalation devices used in the study were used correctly during the study
• The following inclusion criteria apply only to healthy subjects:
• Vital signs were normal at screening
• Pulmonary function was normal during screening
• No smoking or smoking cessation ≥12 months before screening, and previous smoking history <5 pack-years；
• Healthy male 18-50 years old The following inclusion criteria apply only to subjects with COPD
• Male or female, aged 40-75 years;
• Patients diagnosed with COPD;
• A post-bronchodilator FEV1 /FVC < 0.7,40% ≤FEV1 < 80% of the predicted value,;
• Smoking history of≥ 10 pack-years;
• Normal chest X-ray examination results at screening;
• Supporting discontinuation of COPD-related medications before randomization；

You may not qualify if…

• Mean QTcF ≥ 450 ms at screening；
• Persons who had donated blood or had massive blood loss (> 400 ml) within 4 weeks before screening or who were interested in donating blood during the study
• Receipt of the investigational drug or device within 4 weeks before randomization or less than 5 times the half-life of the drug, whichever was greater;
• Patients who had difficulty in blood collection or could not tolerate venipuncture in the past, such as dizzy with needles or blood
• History of malignancy in any organ system
• Known allergies to salbutamol, study medication, or any excipients in the formulation
• Known previous infection with human immunodeficiency virus (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV); Or positive HIV (according to a trial-site SOP), treponema pallidum antibody, HBV surface antigen, or HCV antibody before randomization
• History of alcohol abuse
• History of drug abuse and drug dependence in the past 5 years；
• Positive for alcohol or substance abuse test before randomization
• During the study, surgery or treatment that might interfere with the conduct of the study was planned；
• Unable or unwilling to fully adhere to the study protocol
• Mentally or legally incapacitated
• There were any other reasons for the subject not to participate in the study in the opinion of the investigator;
• Use of a strong/moderate potency drug that inhibits or induces the hepatic drug-metabolizing enzyme CYP3A4 14 days before the first dose;
• Drugs with effects on P-glycoprotein (P-gp) or breast cancer resistance protein (BCRP) were anticipated to be used during the study;
• History of using HRS-9821 suspension;
• The following exclusion criteria apply only to healthy subjects:
• Have been treated with antibiotics for upper and lower respiratory tract infections within 12 weeks prior to screening;
• Abnormal laboratory or physical examination results with clinical significance;
• Positive urine nicotine test before randomization;
• Have consumed a prescription within 14 days prior to the first dose or over-the-counter drugs within 48 h prior to the first dose; The following exclusion criteria apply only to subjects with COPD
• History of life-threatening acute exacerbation of COPD (AECOPD), including admission to intensive care unit and/or need for invasive ventilator support;
• Diagnosed with other respiratory disorders;
• Pulmonary heart disease, or pulmonary hypertension caused by lung disease and/or hypoxia;

Where it is running

• West China Hospital, Sichuan University — Chengdu, Sichuan, China (enrolling)

Full record on ClinicalTrials.gov

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