Desflurane vs. Propofol for Cardiac Anesthesia

Recruiting now · Phase 3

Conditions studied: Cardiac Surgery, Coronary Artery Bypass Grafting

In brief

To investigate whether the inhaled anesthetic desflurane, compared with propofol, exerts cardioprotective effects and reduces the incidence of severe postoperative major cardiac events in patients undergoing coronary artery bypass graft (CABG) surgery.

Key facts

Study ID

NCT07116733

Run by

Xijing Hospital

People needed

3560

Starts

2025-10-20

Expected to finish

2029-12-31

Last updated by the study team

2025-11-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients scheduled for elective coronary artery bypass grafting (CABG)
• Age ≥ 18 years old;
• Sign the informed consent form.

You may not qualify if…

• Emergency or urgent operation
• Concomitant valve or aortic surgery
• History of myocardial infarction in recent 30 days
• Current use of myocardial preconditioning-affecting medications, such as sulfonylurea (glibenclamide), allopurinol, theophylline, nicorandil(last dose < 8 hrs), etc
• Participated in other randomized controlled clinical trials in recent 3 months
• General anesthesia in recent 30 days
• History of kidney and liver transplantation, or severe liver and kidney dysfunction (EGFR ≤ 20 mlgmin/1.73 m2, conventional dialysis or patients who have started dialysis; Child Pugh grade C/cirrhosis)
• History of open heart surgery;
• Hemodynamic instability or severe heart failure (SBP<90 mmHg or preoperative need of high-dose vasoactive drug support, placement of aortic balloon pump (IABP), ECMO or ventricular assist device, left ventricular ejection fraction<30%)
• Adverse drug reactions to trial medications
• History of malignant hyperthermia
• Pregnancy or lactation

Where it is running

• Tianjin Chest Hospital — Tianjin, Tianjin Municipality, China (enrolling)
• Changhai Hospital — Shanghai, China (enrolling)
• Xijing Hospital — Xi'an, Shaanxi, China (enrolling)
• The First Hospital of Hebei Medical University — Shijiazhuang, Hebei, China
• The First Affiliated Hospital of Zhengzhou University — Zhengzhou, Henan, China
• Wuhan Asia Heart Hospital — Wuhan, Hubei, China
• Jiangsu Province Hospital — Nanjin, Jiangsu, China
• Sichuan Provincial People's Hospital — Chengdu, Sichuan, China
• Ningbo No.2 Hospital — Ningbo, Zhejiang, China
• Daping Hospital, Army Medical University — Chongqing, China
• Fuzhou University Affiliated Provincial Hospital — Fuzhou, Fujian, China
• Zhongshan Hospital, Fudan University — Shanghai, China
• Cangzhou People's Hospital — Cangzhou, Hebei, China
• Hebei General Hospital — Shijiazhuang, Hebei, China

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.