Intrapleural Ropivacaine Infusion in Cardiac Surgery
Recruiting now · Phase 4 · Has a placebo group
Conditions studied: Cardiac Surgery, Coronary Artery Disease, Valvular Diseases
In brief
For many patients, a primary source of postoperative pain following cardiac surgery is the presence of pleural drains, which the surgeon places at the end of the operation and maintains for 1 to 3 days. One promising method of pain management after cardiac surgery is interpleural analgesia, particularly when traditional analgesic methods, such as systemic opioids or epidural anesthesia, may be limited due to the risk of complications. Interpleural analgesia involves the introduction of local anesthetics directly into the pleural cavity through drainage tubes placed after cardiac surgery. This method targets pain receptors in the chest area, providing effective analgesia without significant systemic effects. Several clinical studies have confirmed the safety and efficacy of intrapleural administration of anesthetics after thoracic surgery. The aim of this randomised double-blind placebo controlled study is to test the hypothesis that, in patients after cardiac surgery, the quality of recovery from anesthesia with intrapleural use of ropivacaine is superior to that with a placebo.
Key facts
- Study ID
- NCT07116343
- Run by
- Saint Petersburg State University, Russia
- People needed
- 116
- Starts
- 2025-10-22
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-03-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Scheduled cardiac surgery using a standard median sternotomy.
- Planned opening of the pleural cavities.
- Age more than 18 years.
- Signed informed consent to participate in the study.
You may not qualify if…
- Contraindications for ropivacaine
- Redo surgery
Where it is running
- Saint-Petersburg university hospital — Saint Petersburg, Russia (enrolling)
- Primorskiy general hospital #1 — Vladivostok, Russia (enrolling)
Full record on ClinicalTrials.gov
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