µQFR for Branch Stenosis After Single Stent in Bifurcation Lesions

Recruiting now

Conditions studied: Coronary Artery Disease, Coronary Artery Disease (Left Main), Obstructive Coronary Artery Disease, Stent Implantation

In brief

Murray-law based single-view quantitative flow ratio (µQFR) has been recommended for guiding percutaneous coronary intervention (PCI) in selective patients. However, it's reliability has not been validated in bifurcation lesions which present complex anatomy and flluid conditions before and after PCI. The goal of this study is to investigate the diagnostic performance of µQFR in side branch after single-stent treatment for bifurcation lesions in patient with obstructive coronary artery diseases.

Key facts

Study ID

NCT07116083

Run by

Shanghai Zhongshan Hospital

People needed

290

Starts

2025-08-13

Expected to finish

2026-10-31

Last updated by the study team

2026-02-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years and provision of written informed consent for biospecimen donation upon hospital admission.
• Clinical suspicion or diagnosis of CAD requiring coronary angiography and physiological assessment.
• Angiographically confirmed true bifurcation lesions, including but not limited to: left main-left anterior descending-left circumflex (LM-LAD-LCx), left anterior descending-diagonal (LAD-Dg), left circumflex-obtuse marginal (LCx-OM), and right coronary artery-posterior left ventricular-posterior descending artery (RCA-PLV-PDA).
• Bifurcation lesion vessel diameter ≥ 2.5 mm with visually estimated angiographic diameter stenosis ≥ 50%.

You may not qualify if…

• Acute myocardial infarction.
• Cardiogenic shock or severe heart failure (Killip class IV).
• Serum creatinine > 150 μmol/L or estimated glomerular filtration rate (eGFR) < 45 mL/min/1.73 m² calculated using the CKD-EPI formula.
• Known allergy to iodinated contrast media.
• History of coronary artery bypass graft surgery.

Where it is running

• Zhongshan Hospital, Fudan University — Shanghai, Shanghai Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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