Optimal Ventilation for Cardiac Arrest

Recruiting now · Not applicable

Conditions studied: Cardiac Arrest (CA)

In brief

Pediatric cardiac arrest is a life-threatening problem affecting \>15,000 hospitalized children each year. Less than half of these children survive to hospital discharge, and neurologic morbidity is common among survivors. The objective of this study is to evaluate the effectiveness of the OPTI-VENT bundle to improve survival to discharge with favorable neurological outcome (Pediatric Cerebral Performance Category Score 1-2 or no change from baseline) among children receiving at least 1 minute of CPR.

Key facts

Study ID

NCT07114510

Run by

Children's Hospital of Philadelphia

People needed

1530

Starts

2025-10-01

Expected to finish

2030-03-31

Last updated by the study team

2025-10-08

Who can join

Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Invasive airway in place at the start of CPR or airway placed within the first 5 minutes
• Received at least 1 minute of CPR.

You may not qualify if…

• Lack of commitment to aggressive ICU therapies (e.g., CPR performed as part of end-of-life care.
• Brain death determination prior to the CPR event.
• Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes).
• Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR

Where it is running

• CHOC — Orange, California, United States (enrolling)
• Lucile Packard Children's Hospital Stanford — Palo Alto, California, United States (enrolling)
• Children's Hospital Colorado — Denver, Colorado, United States (enrolling)
• Nemours Children's Health — Wilmington, Delaware, United States (enrolling)
• Children's Healthcare of Atlanta — Atlanta, Georgia, United States (enrolling)
• Riley Children's Health — Indianapolis, Indiana, United States (enrolling)
• Stead Family Children's Hospital — Iowa City, Iowa, United States (enrolling)
• Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)
• Washington University in St. Louis — St Louis, Missouri, United States (enrolling)
• Cohen Children's Medical Center — New Hyde Park, New York, United States (enrolling)
• UNC Children's Hospital — Chapel Hill, North Carolina, United States (enrolling)
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States (enrolling)
• Nationwide Children's Hospital — Columbus, Ohio, United States (enrolling)
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States (enrolling)
• Dell Children's Medical Center — Austin, Texas, United States (enrolling)
• Medical City Children's Hospital — Dallas, Texas, United States (enrolling)
• UT Southwestern Medical Center — Dallas, Texas, United States (enrolling)
• Children's Hospital of Richmond at VCU — Richmond, Virginia, United States (enrolling)
• Seattle Children's — Seattle, Washington, United States (enrolling)
• Children's Wisconsin — Milwaukee, Wisconsin, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.