Assessing Upper Extremity Function in Chronic Stroke Survivors Through Acute Intermittent Hypoxia

Running, not enrolling · Not applicable

Conditions studied: Stroke

In brief

Here we aim to observe effects of acute intermittent hypoxia in persons who have experienced a single stroke. We have previously shown this technique to be safe and effective at increasing strength in persons with disabilities, and here are aiming to determine the mechanism of how the breathing method modulates motor function.

Key facts

Study ID

NCT07113457

Run by

Shirley Ryan AbilityLab

People needed

20

Starts

2025-06-02

Expected to finish

2027-08-01

Last updated by the study team

2026-03-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A first time, unilateral, ischemic, hemispheric stroke, confirmed by MRI
• Chedoke stage of hand assessment >= 3
• Ability to open and close affected hand
• Able to understand and communicate in english
• Able to independently consent
• over 6 months post stroke
• Must have a hemoglobin level above 10g/dl
• Must have ability to leave research visit with a compainon/group trasportation
• WOCBP must be comfortable confirming negative pregnancy prior to hypoxia
• Must not be involved in any other research intervention study testing upper extremities

You may not qualify if…

• History of prior neurological disorders
• Brain stem or cerebellar stroke; mean Fazekas score rated on initial fluid-attenuated inversion recovery MRI greater than equal to 3
• Severe Aphasisa
• Pre-existing hypoxic pulmonary disease
• Includes positive Covid-pneumonia diagnosis within 1 year of screening visit
• Severe hypertension (>160/100)
• Any ischemic cardiac disease

Where it is running

• Shirley Ryan AbilityLab — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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