A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis
Recruiting now · Phase 3
Conditions studied: Eosinophilic Esophagitis (EoE)
In brief
This study is researching an experimental drug called dupilumab (called "study drug"). The study is focused on children with active eosinophilic esophagitis (EoE; an inflammatory disease of the esophagus) which impacts feeding and nourishment. The aim of the study is to see how safe, tolerable, and effective the study drug is when given for 24 weeks to children with active EoE. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
Key facts
- Study ID
- NCT07112378
- Run by
- Regeneron Pharmaceuticals
- People needed
- 20
- Starts
- 2025-11-10
- Expected to finish
- 2028-10-09
- Last updated by the study team
- 2026-08-05
Who can join
Age: 1 and older, up to 6. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Phoenix Childrens Hospital — Phoenix, Arizona, United States (enrolling)
- University of California San Francisco (UCSF) — San Francisco, California, United States (enrolling)
- Children's Hospital Colorado — Aurora, Colorado, United States (enrolling)
- GI Care for Kids LLC — Atlanta, Georgia, United States (enrolling)
- Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
- Weill Cornell Medicine — New York, New York, United States (enrolling)
- University of North Carolina, Bioinformatics Building — Chapel Hill, North Carolina, United States (enrolling)
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States (enrolling)
- Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)
- Cook Children's Medical Center — Fort Worth, Texas, United States (enrolling)
- University of Virginia — Charlottesville, Virginia, United States (enrolling)
- Medical College of Wisconsin, Children's Hospital of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
Full record on ClinicalTrials.gov
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