Repetitive Transcranial Magnetic Stimulation Treatment of Stimulant Use Disorder

Starting soon · Not applicable · Has a placebo group

Conditions studied: Stimulant Use Disorder

In brief

The purpose of this study is to establish a new treatment (repetitive transcranial stimulation (rTMS)) for Veterans with stimulant use disorder (SUD). Despite the large public health burden imposed by SUD, there is currently no FDA-approved or widely recognized effective somatic treatment. This placebo controlled study will test the effectiveness of rTMS in the treatment of SUD, and explore biomarkers that may guide patient selection for rTMS treatment and predict treatment response.

Key facts

Study ID

NCT07112105

Run by

VA Office of Research and Development

People needed

106

Starts

2026-05-01

Expected to finish

2029-12-31

Last updated by the study team

2026-04-02

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Structured Clinical Interview for DSM Disorders (SCID) confirmed diagnosis of SUD, severe
• Last use of stimulants >2 and <8 weeks
• Stable medication regimen (no change in dose or agents between 2 weeks prior to the start of and throughout the treatment phase of the study)
• Stable medical health

You may not qualify if…

• Pregnant or lactating female
• History of prior adverse reaction to TMS
• On medications thought to significantly lower seizure threshold, e.g. clozapine, chlorpromazine, clomipramine, and bupropion > 400mg/day
• Seizure disorder or conditions known to substantially increase risk for seizures
• Implants or medical devices incompatible with TMS
• Acute or unstable chronic medical illness that would affect participation or compliance in the study, e.g. unstable angina
• Unstable psychiatric symptoms that precludes consistent participation in the study, e.g. active current suicidal intent or plan; severe psychosis
• Other substance use disorder not in remission
• Chronic or recurring Axis I psychotic disorders
• For subjects participating in fMRI scans, presence of ferromagnetic material in their body or taking DAergic medications

Where it is running

• VA Palo Alto Health Care System, Palo Alto, CA — Palo Alto, California, United States

Full record on ClinicalTrials.gov

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