Neuromodulation and Attention Deficits in MDD

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Major Depression Disorder, Cognitive Deficits, Selective Attention

In brief

Multimodal study (Behavior, TMS, EEG) combining a sham-controlled intermittent theta burst stimulation (iTBS) intervention with an additional-singleton task and EEG to evaluate whether left dorsolateral prefrontal cortex (DLPFC) stimulation enhances cognitive control and modulates maladaptive attention processes in MDD and whether the effects are influenced by neuronavigated versus manual (Beam F3 method) localization of the stimulation site.

Key facts

Study ID

NCT07111169

Run by

University of Electronic Science and Technology of China

People needed

60

Starts

2024-01-01

Expected to finish

2028-12-30

Last updated by the study team

2025-08-08

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-55 years
• Right-handed
• Normal or corrected normal visual acuity
• MDD: meet the proposed DSM-5 MDD criteria, unmedicated or stable medicated within the last one month. Healthy subjects without any past or present psychiatric or neurological disorders.

You may not qualify if…

• Diagnosis of other severe mental disorders, such as schizophrenia, bipolar disorder, neurodevelopmental disorder, etc.
• high suicidal risk
• Unnormal intellectual functioning, auditory impairments,
• Have received neuromodulation, such as Modified Electroconvulsive Therapy (MECT), or any psychotherapy within the past 6 months.
• Only for the active-iTBS group: have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning).

Where it is running

• The Clinical Hospital of Chengdu Brain Science Institute, Chengdu Fourth People's Hospital, Jiujiang Branch (Chengdu Mental Health Center) — Chengdu, Sichuan, China (enrolling)

Full record on ClinicalTrials.gov

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