A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
Recruiting now · Phase 1/Phase 2
Conditions studied: Breast Cancer, Endometrial Cancer, Ovarian Cancer, Lung Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma, Esophageal Squamous Cell Carcinoma, Solid Tumor, Cervical Cancer
In brief
This is a Phase 1/2, open-label, multicenter study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics and anti-tumor activity of TER-2013 in patients with advanced solid tumors harboring AKT/PI3K/PTEN pathway alterations.
Key facts
- Study ID
- NCT07109726
- Run by
- Terremoto Biosciences Inc.
- People needed
- 205
- Starts
- 2025-09-23
- Expected to finish
- 2029-02-28
- Last updated by the study team
- 2026-05-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Florida Cancer Specialists - Lake Nona — Orlando, Florida, United States (enrolling)
- Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
- Mayo Rochester — Rochester, Minnesota, United States (enrolling)
- Washington Univ. School of Medicine — St Louis, Missouri, United States (enrolling)
- Nebraska Cancer Specialists — Omaha, Nebraska, United States (enrolling)
- Carolina BioOncology Institute — Huntersville, North Carolina, United States (enrolling)
- UH Cleveland Medical Center — Cleveland, Ohio, United States (enrolling)
- Sarah Cannon Nashville — Nashville, Tennessee, United States (enrolling)
- NEXT Oncology — Austin, Texas, United States (enrolling)
- MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
- START Center for Cancer Research — San Antonio, Texas, United States (enrolling)
- START Center for Cancer Research — West Valley City, Utah, United States (enrolling)
- NEXT Oncology — Fairfax, Virginia, United States (enrolling)
- Froedtert & MCW Cancer Center — Milwaukee, Wisconsin, United States (enrolling)
- PanOncology Trials — San Juan, Puerto Rico (enrolling)
Full record on ClinicalTrials.gov
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