Effect of Dexamethasone on Labour Induction in Term Pregnancies
Recruiting now · Early Phase 1
Conditions studied: Labor Induction
In brief
The aim of the study is to assess the effect of dexamethasone on labour induction in term pregnancies. Primary outcome: The interval between initiation of induction and beginning of the active phase of labour. Secondary outcomes: * Duration of active phase of labour (starting with cervical dilatation of 4-5 cm up to full cervical dilatation). * Duration of second stage of labour * Mode of delivery. * Fetal outcome. Group A: Will receive one dose of IM dexamethasone sodium phosphate 8 mg (2 mL). Group B: Will receive vaginal misoprostol 25 μg tablets every 6 h, up to 4 tablets, for a maximum duration of 24 h. Group C: Will receive one dose of IM dexamethasone sodium phosphate 8mg (2mL) with the first dose of vaginal misoprostol 25 μg tablets that will be given every 6 h, up to 4 tablets, for a maximum duration of 24 h.
Key facts
- Study ID
- NCT07109258
- Run by
- Cairo University
- People needed
- 150
- Starts
- 2025-05-01
- Expected to finish
- 2025-09-15
- Last updated by the study team
- 2025-08-07
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Age > 18 years.
- Nulliparous.
- Vertex presentation.
- Singleton pregnancy.
- Gestational age ≥ 39 weeks according to a reliable date for the last menstrual period or a first-trimester ultrasound evaluation.
- No contraindication for vaginal delivery.
You may not qualify if…
- Indication for cesarean section e. g. Placenta previa, intrauterine growth retardation, non-vertex presentation and previous cesarean section.
- Maternal medical disorders as diabetes mellitus and severe pre-eclampsia.
- Preterm labour and preterm rupture of membranes.
- Gestational age <39 weeks of gestation.
- Fetal macrosomia > 4kg (estimated by u/s).
Where it is running
- Cairo University Hospital (Kasr Al Ainy) — Cairo, Manial, Egypt (enrolling)
Full record on ClinicalTrials.gov
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