The Effects of Vitamin C on Acute-Exercise in Postmenopausal Females

Stopped early · Not applicable · Has a placebo group

Conditions studied: Females, Males, Menopause, Sedentary, Healthy Participants

In brief

This study is looking at whether vitamin C can help improve oxidative stress and blood vessel health in females after menopause. We will see if taking different amounts of vitamin C for a few days changes how the body handles stress from exercise. This could lead to safer ways to protect females from heart disease without using hormone therapy.

Key facts

Study ID

NCT07109115

Run by

University of Virginia

People needed

1

Starts

2025-09-01

Expected to finish

2026-07-01

Last updated by the study team

2026-07-17

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Post-menopausal (for females; defined as no menstrual cycle for 1-year)
• Sedentary (<150min of moderate-intensity exercise per week or not engaged in a regular exercise program)
• Non-smoking
• Weight stable (+/-3 kg over the past 3 months)

You may not qualify if…

• Overt CVD
• Any condition or medication contraindicating safe exercise
• Hormone replacement therapy (last 3-months)
• Use of vasoactive medications (e.g., calcium channel blockers, statins, ACE inhibitors, ARBs, nitrates, alpha-/beta-blockers, diuretics), diabetes, or unstable medication regimens
• Diabetes
• Oral antibiotic use within previous four weeks
• Oral disease or poor oral health as determined by the Oral Health Questionnaire
• Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use
• Cancer diagnosis

Where it is running

• Student Health and Wellness Building - Department of Kinesiology — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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