Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries
Recruiting now · Not applicable
Conditions studied: Intraoperative Infusion, Lidocaine, Dexmedetomidine, Cerebral Oxygen Saturation, Postoperative Delirium, Elderly Patients, Abdominal Surgeries
In brief
This study aims to compare the effect of intraoperative infusion of either lidocaine or dexmedetomidine on the incidence of postoperative delirium (POD) in elderly patients undergoing major surgeries. It also aims to evaluate the impact of both medications on intraoperative regional cerebral oxygen saturation (rSO₂).
Key facts
- Study ID
- NCT07108764
- Run by
- Tanta University
- People needed
- 100
- Starts
- 2025-04-17
- Expected to finish
- 2027-04-01
- Last updated by the study team
- 2025-08-07
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 65years old.
- Both sexes.
- Physical status classification of II - III according to the American Society of Anesthesiologists (ASA).
- Undergo elective non-cardiac surgeries.
You may not qualify if…
- History of mental illness, neurological illness, or scoring less than 8 using the abbreviated mental test (AMT) before operation.
- Severe hearing or visual impairment that may interfere with communication.
- Severe renal or hepatic dysfunction.
- Patients on central nervous system (CNS) medications (antipsychotics, anticonvulsants, antiparkinsonian, antidepressants).
- Contraindications to lidocaine or dexmedetomidine [e.g., allergy, severe bradycardia, atrioventricular (AV) block].
Where it is running
- Tanta University — Tanta, El-Gharbia, Egypt (enrolling)
Full record on ClinicalTrials.gov
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