Diet and Microbiome Interactions: Application in Posttraumatic Stress Disorder in Adults Consuming Vegetable Drinks
Running, not enrolling · Not applicable
Conditions studied: PTSD - Post Traumatic Stress Disorder
In brief
The gut microbiome has been shown to impact various facets of human health, including mental health. Studies have shown that populations with more agrarian lifestyles tend to have fewer chronic diseases and mental health issues than industrialized populations. A possible factor in these differences is the loss of co-evolved gut microbial taxa that has occurred with Westernization. This hypothesis, termed "Old Friends Hypothesis" suggests that the loss of certain gut microbes leads to immune dysregulation and increased chronic inflammation that contributes to development of cancers, cardiometabolic diseases and even neuroinflammation that can lead to negative behavioral and mental health outcomes. Other studies have shown that increasing the intake of plant foods may help increase diversity of the microbes in the gut and that this increased diversity could lead to better health outcomes in humans. The investigators propose to evaluate daily consumption of a drink consisting of a high diversity of plants (30 plant species) for four weeks on the diversity of the gut microbiome, biological signatures of inflammation, quality of life, sleep quality, and PTSD symptoms among persons with a diagnosis of PTSD. The investigators hypothesize that four weeks of daily consumption of this high plant diversity beverage (30 plant species) will increase gut microbiome ɑ-diversity, reduce markers of systemic inflammation, and improve PTSD symptom severity relative to daily consumption of a beverage containing only three plant species.
Key facts
- Study ID
- NCT07107269
- Run by
- Colorado State University
- People needed
- 40
- Starts
- 2025-06-25
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-07-14
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Healthy adults (18-60 years old)
- Diagnosis of PTSD
- BMI<35
- Willing to follow all study criteria
You may not qualify if…
- Antibiotic use within 3 months
- BMI of 35 or higher
- Vegan or vegetarian
- Allergies to any intervention beverages
- Unstable medication regimen
- Any gastrointestinal diseases, cancer, CVD, diabetes, autoimmune disease, pregnant or breastfeeding
- Any medication changes within last two months
Where it is running
- Food and Nutrition Clinical Research Lab - Colorado State University — Fort Collins, Colorado, United States
Full record on ClinicalTrials.gov
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