Training Induced Muscle-Adipose EV Communication

Starting soon · Not applicable

Conditions studied: Prediabetes

In brief

This study examines how muscle cells communicate with fat cells through tiny packages called extracellular vesicles (EV) during exercise. These vesicles carry important molecules that may affect how the body processes sugar and fat. The research team observed significant variability in the adipose response to exercise, and used this variability to gain further insight into the mechanism through which mature microRNA-1 (miR-1) changes in adipose tissue. The investigators selected six subjects with the highest increase in miR-1 abundance in adipose tissue after exercise and compared them with the six subjects that had the most dramatic decrease in miR-1 abundance after exercise. The research team observed that participants intrinsically vary in their ability to endocytose EV into adipose tissue. It is unclear whether this variance in receptivity is a cause or consequence of the significant difference in EV-delivery of miR-1 to adipose tissue.

Key facts

Study ID

NCT07106450

Run by

Yuan Wen

People needed

40

Starts

2026-09-01

Expected to finish

2028-09-30

Last updated by the study team

2026-08-10

Who can join

Age: 30 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 30-55 years
• Sedentary lifestyle (exercise <1 day/week for at least 3 months prior to enrollment)
• Able to provide informed consent
• For Control Group: BMI < 27 kg/m², normal glucose tolerance, no more than 1 feature of metabolic syndrome
• For Prediabetic Group: BMI > 30 kg/m², at least 3 features of metabolic syndrome including prediabetes (defined as fasting plasma glucose 100-125 mg/dL OR 2-hour post-load glucose on 75g OGTT 140-199 mg/dL OR HbA1C 5.7-6.4%)

You may not qualify if…

• Pregnancy (confirmed by pregnancy test in women of childbearing potential)
• Type 2 diabetes mellitus
• Cardiovascular contraindications to resistance exercise
• Medical conditions that would interfere with muscle or adipose tissue biopsy procedures
• Use of medications that significantly affect glucose metabolism or exercise response
• Active participation in structured exercise programs (>1 day/week) within 3 months of enrollment
• Inability to safely participate in resistance exercise protocol

Where it is running

• University of Kentucky — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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