Indole-3-PROpionic Acid Clinical Trials - a Pilot Study Part 2
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Healthy
In brief
The goal of this trial is to investigate the biological effects of oral supplementation with indole-3-propionic acid (IPA) taken twice daily in healthy adults. The main scientific questions are: * Does supplementation with IPA increase the abundance of regulatory T cells in the blood? Regulatory T cells are believed to play an important role in preventing autoimmune diseases. * Does supplementation with IPA increase the concentration of brain-derived neurotrophic factor (BDNF) in the blood? BDNF is believed to play an important role in maintaining brain health. * Does supplementation with IPA affect blood analyses commonly performed to assess the risk of metabolic disorders like type 2 diabetes and cardiovascular diseases? Participants will: * Take capsules to achieve a total daily dose of 1000 mg of IPA or placebo: 500 mg every morning and 500 mg every evening for 14 days. * Visit the clinic at the beginning (day 1) and at the end (day 15) of the supplementation period to deliver blood, urine and fecal samples, have simple measurements performed, fulfil questionnaires and report any side effects.
Key facts
- Study ID
- NCT07105514
- Run by
- Glostrup University Hospital, Copenhagen
- People needed
- 32
- Starts
- 2025-08-04
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2025-08-08
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy women and men ≥18 and ≤65 years of age
- Deemed mentally and physically able to participate
You may not qualify if…
- Diagnosis of gut-, heart-, liver-, kidney or immune-related disorders
- Use of antibiotics within the last month
- Pregnancy, lactation or childbirth within the last five months
- Use of prescription medication
Where it is running
- Optic Neuritis Clinic, Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet-Glostrup — Glostrup Municipality, Denmark (enrolling)
Full record on ClinicalTrials.gov
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