Exploring Efficacy of Multi-Mode Cognitive Processing Therapy (CPT) for PTSD

Recruiting now · Not applicable

Conditions studied: Posttraumatic Stress Disorder

In brief

This study is a longitudinal, multicenter, single-blind, two-arm randomized controlled trial designed to evaluate the effectiveness of Multi-Modal Cognitive Processing Therapy (MMCPT) for individuals with posttraumatic stress disorder (PTSD). Participants will be randomly assigned to either the intervention group receiving MMCPT or a control group receiving treatment-as-usual (TAU). The intervention follows the standard CPT manual developed by Resick and consists of twelve weekly 90-minute individual sessions. The primary outcomes include PTSD symptom severity assessed by the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) and the PTSD Checklist for DSM-5 (PCL-5). Secondary outcomes include sleep quality (actigraphy, PSQI), anxiety (STAI), depression (HDRS-17), remission rate, and posttraumatic growth (PTGI). Assessments will occur at baseline, mid-treatment, post-treatment, and at 3-, 6-, 9-, and 12-month follow-ups.

Key facts

Study ID

NCT07105345

Run by

Far Eastern Memorial Hospital

People needed

60

Starts

2025-09-01

Expected to finish

2027-12-31

Last updated by the study team

2026-03-20

Who can join

Age: 20 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged between 20 and 65 years
• Diagnosed with PTSD according to DSM-5 criteria
• Score ≥ 33 on the PTSD Checklist for DSM-5 (PCL-5)
• Able to provide informed consent
• Stable psychiatric medication regimen (if any) for at least 4 weeks prior to enrollment

You may not qualify if…

• Diagnosed with schizophrenia, schizoaffective disorder, or bipolar I disorder
• Current substance dependence or abuse within the past 6 months
• Severe suicidal ideation or suicide attempt in the past 6 months
• Cognitive impairment or neurological disorder affecting participation
• Concurrent participation in other psychological treatment for PTSD

Where it is running

• Far Eastern Memorial Hospital — New Taipei City, Banqiao District, Taiwan (enrolling)
• Far Eastern Memorial Hospital — New Taipei City, Banqiao District, Taiwan

Full record on ClinicalTrials.gov

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